Abstract:

A hallmark of inflammatory responses is leukocyte mobilization, which is mediated by bacterial and host tissue-derived chemotactic factors that activate Gi-protein-coupled seven-transmembrane receptors (GPCRs) expressed on host cell surface. Formylpeptide receptors (FPRs, Fprs in mice) are members of the chemoattractant GPCR family, shown to be critical in myeloid cell trafficking during infection, inflammation, immune responses and cancer progression. Accumulating evidence demonstrates that both human FPRs and murine Fprs are involved in many patho-physiological processes because of their expression on a wide variety of cell types in addition to myeloid cells. The unique capacity of FPRs (Fprs) to interact with numerous structurally unrelated, pathogen- as well as host-derived, chemotactic ligands enables these receptors to participate in orchestrated disease initiation, progression and resolution. One murine Fpr member, Fpr2, and its endogenous agonist peptide, Cathelicidin-related antimicrobial peptide (CRAMP), have been demonstrated as key mediators of colon mucosal homeostasis and protection from inflammation, dysbiosis and associated tumorigenesis. Recent availability of genetically engineered mouse models greatly expanded the understanding of the role of FPRs (Fprs) in pathophysiology that places these molecules in the list of potential targets for therapeutic intervention of diseases.

Biography:

Dr. Wang received his M.D. degree in 1983 at Shanghai Second Medical University (currently Shanghai Jiaotong University School of Medicine) Graduate School at the Faculty of Chest Surgery, majoring in the Surgical and Immunological Therapy of Lung Cancer, in Shanghai, P. R. China. In 1987, he obtained a Ph.D. degree at the Lombardy School for High Education with the major in Immunology (located at the Mario Negri Pharmacological Research Institute with Dr. Alberto Matovani as the mentor), Milan, Italy. Dr. Wang joined the National Cancer Institute at Frederick in 1990 as a Visiting Scientist (with Dr. Joost J. Oppenheim as the mentor). He then became an independent Principal Investigator in 1996. In 2002, he was promoted to the position of tenured Senior Investigator. Dr. Wang’s major research interest is the role of G-protein coupled chemoattractant receptors (GPCRs) in pathophysiological conditions.

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