Emergence of antimicrobial resistance worldwide is responsible for alarming situation. There is an urgent need to discover more effective, safer and less toxic antibacterial agents. Medicinal plants are valuable alternative resources for developing novel drugs. In the present study hexane and acetone extracts of Tachyspermum ammi seeds, Amomum subulatum fruit and Cinnamomum verum bark, independently and in combinations were used to evaluate invitro antibacterial efficacies against four clinical bacterial strains such as E. coli, S. aureus, P. aeruginosa and S. epidermidis. Antibacterial activity of various combinations of these three plant extracts reported for the first time in order to determine synergistic potential and pharmacological interactions. Ciprofloxacin served as positive control antibiotic. Zone of inhibitions of plant extracts was compared with standard antibiotic ciprofloxacin. Our findings reported that clinical strains E. coli and S. aureus that were completely resistant to Ciprofloxacin showed tremendous susceptibility towards separate and combined plant extracts. Most susceptible strain towards plant extracts was S. aureus followed by E. coli, S. epidermidis and P. aeruginosa. Most resistant strain towards plant extracts was P. aeruginosa. It was noted that prominent synergism occurred in most of the combined plant extracts highlighting medical importance for combating infections caused by multidrug resistant bacteria. Current study clearly suggests that various combinations of these three plant extracts could be used as potential natural resources in order to develop promising antibiotic for treating various infections.
Dr. Asma Waheed Qureshi has completed her PhD from University of The Punjab, Pakistan in Zoology. Currently she is working as Associate Professor and Head of The Department of Zoology, GC Women University Sialkot, Pakistan. She is also supervising PhD and MS research Scholars and more than 15 MS scholars has completed their degree under her supervision. She has also published more than 25 research articles in reputed journals and presented papers in national and international conferences. Her research focus are parasites and bacterial pathogens of animals and humans.