Antimicrobial resistance (AMR) is one of the most critical challenges in our modern society. It was predicted that there could be more than 10 million death related to AMR in 2050. The overuse of antibiotics, including non-therapeutic applications such as agriculture and environmental disinfection, represents one of the main causes for antimicrobial resistance. On the other hand, up to 80% of the germs are transmitted via surface contact. Therefore, killing bacteria on the frequently touched surfaces is an effective way to avoid cross-infection. The common method to kill bacteria on these surfaces relies on organic disinfectants (small molecules and polymers or organic coatings) which may lead to secondary contamination and drug resistance. Herein, we will introduce novel non-resistance, nano-structured antimicrobial technologies and green surface disinfection technology. Our disinfection surface technology coats various surfaces with nanopatterns which kill adhered bacteria and fungi due to their physical structure through a rupturing mechanism or due to secondary ROS mechanism. These disinfecting surface and antimicrobial technologies are clean and safe, require no externally applied chemicals and can reduce healthcare-associated infections.


Dr. Yugen Zhang is a Group Leader at the Institute of Bioengineering and Nanotechnology (IBN), A-Star, Singapore. He graduated from the University of Science and Technology of China (USTC), where he received his PhD in Chemistry in 1992. After his PhD, he joined USTC as a faculty member and was promoted to Professor in 1999. He visited Riken (Japan) (1996 to 1997, 2000 to 2001), where he worked as visiting scholar in Prof. Zhaomin Hou’ group. Before he joined IBN in 2004, he had been working at Harvard University as a post-doctoral research associate in Prof. RH Holm’s group (2002-2004). His main research areas are green catalysis, nanomaterials and biomaterials.