Tuberculosis is one of the global health problems, the estimated deaths due to TB was around 2 million in the year 2013. Failure in early diagnosis and providing suitable treatment leads to increase the prognosis of the disease. Smear microscopy is used in many countries as a primary diagnosis of TB especially in the district poor facility laboratories, where smear negative frequency is high. This review aimed to reflects the importance of smear negative tuberculosis as a source of infection and poor prognosis of TB treatment and prevention. In addition to, discuss the possible causes and suggests solutions to improve the yields of smear microscopy.


Dr. Tarig Mohamed Saad Alnour (M.Sc, Ph.D in Microbiology and Immunology) Assistant professor, Faculty of Applied Medical Sciences – University of Tabuk Assistant professor, Faculty of Medical Laboratory Sciences, AlZaiem AlAzhari University Medical Laboratory consultant – Microbiology and immunology Interested in Tuberculosis research; Drug resistance development; and Immune susceptibility to infectious diseases.